If you’re a Nvidia or Intel user and you’re using a modern GPU, then this will likely fix the issue – Fallout 3 was never designed to be compatible with anything more than duel-core processors. – Download the Fallout 3 Unofficial patch – Download FOSE (Fallout Script Extender) for Fallout 3 If you continue to experience crashes on startup, consider a few of these fixes
Once you have run them and made sure they’re installed, you should be good to go. Alternatively, you can look in the location bar and select “GFWLive” In order to do this, click the option “Log Folder”, which should take you to this screen